Grayson is located in the Piedmont region of the Southeastern United States, characterized by gently rolling hills and dense canopies of deciduous and coniferous trees, notably Georgia pines, oaks, and hickories. Situated in the southeastern portion of Gwinnett County, Grayson is landlocked and relies heavily on local creeks and streams for its natural water features.
The city sits near the drainage divides for the Yellow River and the Alcovy River basins. The surrounding geography is highly favorable for residential development, featuring stable soils (predominantly the region's famous Georgia red clay) and a lack of severe topographical barriers. The natural environment is carefully preserved in local green spaces and community parks, maintaining a wooded, suburban feel.

